bs-82110C

DATASHEET

Formulation beige solid

Storage: -20°C

Product Information:

A potent and reversible AMP-activated protein kinase (AMPK) allosteric activator. Activates AMPK by binding to the  and  subunits and not the AMP binding site1. EC50=0.8 M for purified rat liver AMPK and inhibits fatty acid biosynthesis in rat hepatocytes IC50=3.2 M2. Inhibits the rate of whole-body fatty acid oxidation, decreases body weight gain, reduces plasma and liver triglycerides and lowers plasma glucose in ob/ob mice2. Inhibits adipocyte differentiation3. Prevents transcriptional activation of Oct4 and establishes a metabolic barrier to induced pluripotent stem cell reprogramming4. Synergizes with AICAR5. Cell permeable.

Description:

CAS Number: 844499-71-4; Chemical Name: 4-Hydroxy-3-(2’-hydroxy-[1,1’-biphenyl]-4-yl)-6-oxo-6,7-dihydrothieno[2,3-b]pyridine-5-carbonitrile; Molecular weight: 360.39; Formula: C20H12N2O3S; Solubility: DMSO (30 mg/ml) Ethanol (5 mg/ml); Physical Properties: Beige solid; Purity: 98% by HPLC, NMR (Conforms)

Size: 5mg, 25mg

Applications: Life Science(N/A)

For research use only. Not intended for diagnostic or therapeutic use.