bs-82110C

DATASHEET

Formulation Beige solid

Storage: -20°C

Product Information:

A potent and reversible AMP-activated protein kinase (AMPK) allosteric activator. Activates AMPK by binding to the  and  subunits and not the AMP binding site1. EC50=0.8 M for purified rat liver AMPK and inhibits fatty acid biosynthesis in rat hepatocytes IC50=3.2 M2. Inhibits the rate of whole-body fatty acid oxidation, decreases body weight gain, reduces plasma and liver triglycerides and lowers plasma glucose in ob/ob mice2. Inhibits adipocyte differentiation3. Prevents transcriptional activation of Oct4 and establishes a metabolic barrier to induced pluripotent stem cell reprogramming4. Synergizes with AICAR5. Cell permeable.

Description:

CAS Number: 844499-71-4 Chemical Name: 4-Hydroxy-3-(2’-hydroxy-[1,1’-biphenyl]-4-yl)-6-oxo-6,7-dihydrothieno[2,3-b]pyridine-5-carbonitrile Molecular weight: 360.39 Formula: C20H12N2O3S Solubility: DMSO (30 mg/ml) Ethanol (5 mg/ml) Physical Properties: Beige solid Purity: 98% by HPLC, NMR (Conforms)