bs-82152C

DATASHEET

Formulation Pale yellow solid

Storage: -20°C

Product Information:

After incorporation into DNA, it disrupts cytosine methylation by DNA methyltransferases in vitro and acts as a DNA demethylating agent in vivo.1 It reactivates epigenetically silenced genes in acute lymphoblastic leukemia cells by facilitating proteasome-mediated degradation of DNA methyltransferase (DNMT1).2 Incorporates into DNA and induces double strand breaks which destabilize DNA structure resulting in cytotoxicity.3 Selectively kills BRCA2-defective tumors and overcomes PARP inhibitor resistance in a xenograft model.4 Anticancer and immunosuppressive activity.

Description:

CAS Number: 154-42-7; Chemical Name: 2-Amino-6-mercaptopurine; Molecular weight: 167.19; Formula: C5H5N5S; Solubility: DMF (1.5 mg/ml); Physical Properties: Pale yellow solid; Purity: 96% by HPLC NMr (Conforms)

Size: 100mg, 1g

Applications: Life Science(N/A)

For research use only. Not intended for diagnostic or therapeutic use.