bs-82157C

DATASHEET

Formulation Cream-colored solid

Storage: -20°C

Product Information:

A high affinity synthetic ligand for both RORα and RORγt acting as an inverse agonist. It binds specifically to the ligand-binding domain, inducing a conformational change which leads to diminished affinity for co-activators and increased affinity for co-repressors resulting in suppression of transcriptional activity1. It inhibits the development of murine TH17 cells2 and suppresses the expression of cytokines1. Suppresses insulitis and prevents hyperglycemia in a type 1 diabetes mouse model3. Protects against pathologic neovascularization in various mouse models of retinopathy4. Active in vivo

Description:

CAS Number: 1335106-03-0 Chemical Name: N-(5-(N-(4-(1,1,1,3,3,3-Hexafluoro-2-hydroxypropan-2-yl)phenyl)sulphamoyl)-4-methylthiazol-2-yl)acetamide Molecular weight: 477.39 Formula: C15H13F6N6O4S2 Solubility: DMSO (40 mg/ml) Ethanol (40 mg/ml) Physical Properties: Cream-colored solid Purity: 98% by TLC, NMR (conforms)