bs-82183C

DATASHEET

Formulation White Solid

Storage: -20°C

Product Information:

24(S)-Hydroxycholesterol is an important cholesterol metabolite (cholesterol 24-hydroxylase) found in the brain.1 It is an endogenous agonist of the nuclear receptor LXR.2 It has been shown to induce cell death in neuroblastoma cells3, possibly via a necroptosis pathway4. 24(S)-Hydroxycholesterol has also been found to be a high affinity ligand for RORα and RORγ (Ki = 25 nM).5 24(S)-Hydroxycholesterol levels are elevated in the cerebral spinal fluids of patients with neurogenerative diseases suggesting possible clinical applications.6,7 It was also able to reduce Aβ production and increase ER-resident immature amyloid precursor protein (APP) levels in human neuroblastoma SH-Sy5Y cells and CHO cells via inhibition of intracellular amyloid precursor protein trafficking.7

Description:

CAS Number: 474-73-7; Chemical Name:; Molecular weight: 402.66; Formula: C27H46O2; Solubility: DMSO (10 mg/ml) Ethanol (10 mg/ml); Physical Properties: White solid; Purity: 99% by HPLC, NMR (Conforms)