bs-82199C

DATASHEET

Formulation White Solid

Storage: -20°C

Product Information:

Inhibitor of transcription factor LSF specifically targeting its DNA binding and corresponding transcriptional activity (IC50=2.1 M). Rapidly induces apoptosis in an aggressive hepatocellular carcinoma (HCC) cell line and dramatically inhibits tumor growth in a mouse xenograft model with no general tissue cytotoxicity.1,2 In human HCC cells, FQI1 induced mitotic arrest with an accompanying increase in cyclin B1.3 Blocks LSF-stimulated activation of DNA methyltransferase 1.4 Cell permeable.

Description:

CAS Number: 599151-35-6; Chemical Name: 8-(2-Ethoxyphenyl)-7,8-dihydro-[1,3]dioxolo[4,5-g]quinoline-6(5H)-one; Molecular weight: 311.33; Formula: C18H17NO4; Solubility: DMSO (50 mg/ml) Ethanol (20 mg/ml); Physical Properties: White solid; Purity: 98% by TLC NMR (conforms)

Size: 5mg, 25mg

Applications: Life Science(N/A)

For research use only. Not intended for diagnostic or therapeutic use.