bs-82205C
[Life Science]
Spautin-1
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support@biossusa.com
800.501.7654 [DOMESTIC]
+1.781.569.5821 [INTERNATIONAL]
DATASHEET
Formulation Tan solid
Storage: -20°C
Product Information:
A specific and potent autophagy inhibitor. Spautin-1 promotes the degradation of Vps34 PI3 kinase complexes by inhibiting two ubiquitin-specific proteases USP10 and USP13 which target the Beclin-1 subunit of Vps34 complexes1. Deranges dengue virion maturation2. Inhibits autophagy in a Beclin-1 independent manner in primary epithelial ovarian cancer cells3. Selectively induces cell death of mutant p53-expressing cancer cell lines under confluency4. Cell permeable.
Description:
CAS Number: 1262888-28-7<br></br>Chemical Name: 6-Fluoro-N[(4-fluorophenyl)methyl]-4-quinazolinamine<br></br>Molecular weight: 271.27<br></br>Formula: C15H11F2N3 <br></br>Solubility: DMSO (50 mg/ml) Ethanol (15 mg/ml with warming)<br></br>Physical Properties: Tan solid<br></br>Purity: 98% by TLC, NMR (Conforms)
Size: 5mg, 25mg
Applications: Life Science
For research use only. Not intended for diagnostic or therapeutic use.