bs-82219C

DATASHEET

Formulation Yellow waxy solid

Storage: -20°C

Product Information:

Histone demethylase JMJD3/UTX inhibitor. Inhibits demethylation of histone H3K27. Reduces LPS-induced proinflammatory cytokine production in primary human macrophages (IC50 = 9 μM for the inhibition of TNFα release). Cell permeable, ethyl ester of GSK J11. Rescues newborn pups from embryonic lethality in BRAF knockin mice which recapitulate major features of RASopathies2.

Description:

CAS Number: 1373423-53-0; Chemical Name: N-[2-(2-Pyridinyl)-6-(1,2,4,5-tetrahydro-3H-3-benzazepin-3-yl)-4-pyrimidinyl]-β-alanine ethyl ester; Molecular weight: 417.48; Formula: C24H27N5O2; Solubility: DMSO (40 mg/ml) Ethanol (40 mg/ml); Physical Properties: Yellow waxy solid; Purity: 99% by TLC, NMR (Conforms)

Size: 5mg, 25mg

Applications: Life Science(N/A)

For research use only. Not intended for diagnostic or therapeutic use.