bs-82222C
[Life Science]
BI-6015
www.biossusa.com
support@biossusa.com
800.501.7654 [DOMESTIC]
+1.781.569.5821 [INTERNATIONAL]
support@biossusa.com
800.501.7654 [DOMESTIC]
+1.781.569.5821 [INTERNATIONAL]
DATASHEET
Formulation Tan solid
Storage: -20°C
Product Information:
Hepatocyte nuclear factor 4α (HNF4α) antagonist. HNF4α is a central regulator of gene expression in cell types that play a central role in metabolic homeostasis. 1 BI-6015 binds to HNF4α with high affinity and modulates the expression of known target genes. It was shown to be selectively cytotoxic to cancer cell lines in vitro and in vivo however in vivo potency was limited by suboptimal pharmacokinetics. 2 Represents the first small molecule tool for pharmacologic modulation of HNF4α activity. 2 Cell permeable.
Description:
CAS Number: 93987-29-2<br></br>Chemical Name: 2-Methyl-1-[(2-methyl-5-nitrophenyl)sulfonyl]-1H-benzimidazole<br></br>Molecular weight: 331.35<br></br>Formula: C15H13N3O4S<br></br>Solubility: DMSO (25 mg/ml) Ethanol (10 mg/ml)<br></br>Physical Properties: Tan solid<br></br>Purity: 98% by TLC, NMR (Conforms)
Size: 5mg, 25mg
Applications: Life Science
For research use only. Not intended for diagnostic or therapeutic use.