bs-82231C

DATASHEET

Formulation beige solid

Storage: -20°C

Product Information:

A novel inhibitor of the growth and proliferation of breast cancer stem cells (CSC) discovered in a phenotypic screen employing CSC-like cells produced by inducing human breast epithelial cells into an epithelial-to-mesenchymal transdifferentiated state (HMLE_sh_ECad). ML239 displayed an IC50=1.18 μM against HMLE_sh_ECad and demonstrated a >23-fold selectivity over control cells. It was also toxic to two other CSC-like lines1,2. Gene expression studies showed altered gene expression in the NFκB pathway1 and support activation of fatty acid desaturase 2 (FADS2) as a potential mechanism of action for ML239.3

Description:

CAS Number: 1378872-36-6; Chemical Name: (2,4,6-Trichlorophenoxy)-acetic acid (1H-pyrrol-2-ylmethylene)-hydrazide; Molecular weight: 346.60; Formula: C13 H10 Cl3 N3 O2; Solubility: DMSO (25 mg/ml) DMF (25 mg/ml) Ethanol (25 mg/ml); Physical Properties: Beige solid; Purity: 98% by TLC, NMr (Conforms)

Size: 5mg, 25mg

Applications: Life Science(N/A)

For research use only. Not intended for diagnostic or therapeutic use.