bs-82245C

DATASHEET

Formulation Light brown solid

Storage: -20°C

Product Information:

A potent and selective inhibitor of tryptophan 2,3-dioxygenase (TDO) Ki=42 nM)1,2. Displays no activity against indoleamine 2,3-dioxygenase, MAO-A and B and does not effect serotonin uptake. Elevates CSF tryptophan by up to 260% and CSF serotonin by 170% of basal2. TDO inhibition by 680C91 in glioma cells blocked the release of kynurenine, an endogenous tumor promoting AHR ligand4.

Description:

CAS Number: 163239-22-3; Chemical Name: 6-Fluoro-3-[(1E)-2-(3-pyridinyl)ethenyl]-1H-indole; Molecular weight: 238.27; Formula: C15H11FN2; Solubility: DMSO (20 mg/ml) Ethanol (10 mg/ml); Physical Properties: Light brown solid; Purity: 98% by TLC, NMR (Conforms)

Size: 5mg, 25mg

Applications: Life Science(N/A)

For research use only. Not intended for diagnostic or therapeutic use.