bs-82266C
[Life Science]
AI-1
www.biossusa.com
support@biossusa.com
800.501.7654 [DOMESTIC]
+1.781.569.5821 [INTERNATIONAL]
support@biossusa.com
800.501.7654 [DOMESTIC]
+1.781.569.5821 [INTERNATIONAL]
DATASHEET
Formulation Off-white solid
Storage: -20°C
Product Information:
A novel antioxidant response element (ARE) activator which activates Nrf2 by covalently modifying Keap1 (Kelch-like ECH-associated protein 1) a negative regulator of Nrf2. Modification of Cys151 of Keap1 by AI-1 disrupts the ability of Keap1 to searve as an adaptor for Cul3-Keap1 ubiquitin ligase complex, thereby stabilizing and inducing transcriptional activation of Nrf2. A useful pharmacological tool for probing the involvement of Nrf2 in cellular physiology1. Cell permeable.
Description:
CAS Number: 75483-04-4<br></br>Chemical Name: 4-Chloro-1,2-dihydro-1-methyl-2-oxo-3-quinolinecarboxylic acid ethyl ester<br></br>Molecular weight: 265.70<br></br>Formula: C13H12ClNO3<br></br>Solubility: DMSO (15 mg/ml)<br></br>Physical Properties: Off-white solid<br></br>Purity: 98% by HPLC NMR (Conforms)
Size: 5mg, 25mg
Applications: Life Science
For research use only. Not intended for diagnostic or therapeutic use.