bs-82277C

DATASHEET

Formulation Light brown solid

Storage: RT

Product Information:

A novel small molecule thought to be an agonist at the glial cell line-derived neurotrophic factor (GDNF) family receptor α-1 GFRα-1. It inhibits radiolabeled GDNF binding in Neuro-2A cells in a concentration dependent manner IC50=10.4 μM. Like GDNF, it induced Ret autophosphorylation and promoted neurite outgrowth in Neuro-2A cells1. Recent studies indicate that it enhances GFRα family receptor signaling in conjunction with ligand stimulation. Effective treatment for small-fiber neuropathy in mouse models of the disease.2,3 GDNF agonists may be a new class of Parkinson’s disease therapeutics.4

Description:

CAS Number: 10023-54-8 Chemical Name: (E)-N4-(7-chloro-2-(2-chlorostyryl)quinolin-4-yl)-N1,N1-diethylpentane-1,4-diamine 3(H3PO4) Molecular weight: 750.45 Formula: C26H31Cl2N3 · 3(H3PO4) Solubility: DMSO (25 mg/ml) Physical Properties: Light brown solid Purity: 98% by TLC, NMR (Conforms)