bs-82311C [Life Science]
L524-0366
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Formulation Beige solid

Storage: -20°C

Product Information:

Fn14 antagonist. Competes with TNF-like weak inducer of apoptosis (TWEAK) C-terminal/extracellular TNF homology domain (THD) for Fn14 binding (KD = 7.12 µM). It specifically inhibits TWEAK-Fn14-mediated NFκB activation. It completely suppressed TWEAK-induced T98G cell migration (10 μM) without cytotoxicity up to 50 μM1. L524-0366 is the first compound known to interfere with the TWEAK/Fn14 inter-action and may serve as a lead compound for the development of new therapeutics2.

Description:

CAS Number: 951612-19-4<br></br>Chemical Name: (1-(3-Chlorophenyl)-1H-1,2,3-triazol-4-yl)(thiomorpholino)methanone<br></br>Molecular weight: 308.79<br></br>Formula: C13H13ClN4OS<br></br>Solubility: DMSO (14 mg/ml) Ethanol (2 mg/ml) <br></br>Physical Properties: Beige solid<br></br>Purity: 98% by TLC, NMR (Conforms)

Size: 5mg, 25mg

Applications: Life Science

For research use only. Not intended for diagnostic or therapeutic use.