bs-82317C

DATASHEET

Formulation Pale yellow solid

Storage: -20°C

Product Information:

Potent and selective p97 AAA ATPase inhibitor, IC50=100 nM. Inhibits degradation of a p97-dependent but not p97-independent proteasome substrate in a dual-reporter cell line1. It impairs the endoplasmic reticulum-associated degradation (ERAD) pathway.1 ML241 and related inhibitors (DBeQ for example) have differential responses to p97 mutants as well as the presence of cofactors suggesting the possibility of context-dependent p97 inhibitors.2,3

Description:

CAS Number: 1346528-06-0; Chemical Name: N-Benzyl-2-(2,3-dihydro-1,4-benzoxazin-4-yl)-5,6,7,8-tetrahydroquinazolin-4-amine; Molecular weight: 372.46; Formula: C23H24N4O; Solubility: DMSO (50 mg/ml) Ethanol (14 mg/ml); Physical Properties: Pale yellow solid; Purity: 98% by HPLC NMR (conforms)

Size: 5mg, 25mg

Applications: Life Science(N/A)

For research use only. Not intended for diagnostic or therapeutic use.