bs-82333C

DATASHEET

Formulation Off-white solid

Storage: -20°C

Product Information:

Potent and selective inhibitor of 3-phosphoglycerate dehydrogenase (PHGDH), IC50=33 μM1. The action of PHGDH is the first committed step of serine biosynthesis2 and certain cancer cells overexpress PHGDH3. CBR-5884 inhibits serine biosynthesis in cells with no effect on two other dehydrogenases, lactate dehydrogenase and MDH1 and without general cytotoxic effects up to 40 μM. CBR-5884 is selectively toxic to tumor cells with high serine synthesis activity. A novel tool for selective inhibition of serine biosynthesis in cells which also provides further proof that PHGDH is a viable target for the development of novel anticancer agents1.

Description:

CAS Number: 681159-27-3 Chemical Name: Ethyl 5-(furan-2-carboxamido)-3-methyl-4-thiocyanatothiophene-2-carboxylate Molecular weight: 336.39 Formula: C14H12N2O4S2 Solubility: DMSO (50 mg/ml) DMF (50 mg/ml) Physical Properties: Off-white solid Purity: 98% by TLC, NMR (Conforms)