bs-82398C

DATASHEET

Formulation White Solid

Storage: -20°C

Product Information:

Potent inhibitor of VEGFR-2, -3, and -1, IC50 = 0.2, 0.1-0.3, and 1.2 nM respectively1 displaying minimal activity against a panel of ~100 protein kinases. Inhibits angiogenesis and vascular permeability.2 Also inhibits BCR-ABL1 (T315I) with high potency, Ki = 149 pM for autophosphorylated ABL1 (T315I).3 Inhibits proliferation of Ba/F3 cells expressing BCR-ABL1 (T315I). Clinically useful anticancer agent.4

Description:

CAS Number: 319460-85-0; Chemical Name: N-Methyl-[[3-[(1E)-2-(2-pyridinyl)ethenyl]-1H-indazol-6-yl]thio]benzamide; Molecular weight: 386.47; Formula: C22H18N4OS; Solubility: DMSO (30 mg/ml); Physical Properties: White solid; Purity: 99% by HPLC, NMR (Conforms)

Size: 10mg, 50mg

Applications: Life Science(N/A)

For research use only. Not intended for diagnostic or therapeutic use.