DATASHEET
Formulation
white or off-white solid
Storage:
-20°C
Product Information:
Potently and selectively inhibits p38 MAPK by simultaneously binding to the ATP-binding domain and an allosteric site.1 (IC50=18 nM). Displays anti-inflammatory activity2 but differential effects on inflammatory genes3. Cell permeable.
Description:
CAS Number: 285983-48-4; Chemical Name: 1-[5-tert-Butyl-2-(4-methylphenyl)pyrazol-3-yl]-3-[4-(2-morpholin-4-ylethoxy)naphthalene-1-yl]urea; Molecular weight: 527.66; Formula: C31H37N5O3; Solubility: DMSO (50 mg/ml) Ethanol (30 mg/ml); Physical Properties: White or off-white solid; Purity: 98% by TLC, NMR (Conforms)