bs-82405C
[Life Science]
Enzastaurin
www.biossusa.com
support@biossusa.com
800.501.7654 [DOMESTIC]
+1.781.569.5821 [INTERNATIONAL]
support@biossusa.com
800.501.7654 [DOMESTIC]
+1.781.569.5821 [INTERNATIONAL]
DATASHEET
Formulation Orange solid
Storage: -20°C
Product Information:
Potent and selective PKCβ inhibitor. IC50 = 6, 39, 83 and 110 nM, for PKCβ, PKCα, PKCγ and PKCε respectively.1 Induces apoptosis in multiple myeloma cell lines via inhibition of the AKT signaling pathway.2 Induces mitotic missegregation and preferential cytotoxicity in colorectal cancer cells with chromosomal instability.3 Attenuates ampheta-mine-stimulated dopamine efflux.4 Inhibits blood-brain barrier leakiness in a mouse model.5
Description:
CAS Number: 170364-57-5<br></br>Chemical Name: 3-(1-Methyl-1H-indol-3-yl)-4-[1-[1-(2-pyridinylmethyl)-4-piperidinyl]-1H-indol-3-yl]-1H-pyrrole-2,5-dione<br></br>Molecular weight: 515.61<br></br>Formula: C32H29N5O2<br></br>Solubility: DMSO (7 mg/ml)<br></br>Physical Properties: Orange solid<br></br>Purity: 99% by HPLC, NMR (Conforms)
Size: 5mg, 25mg
Applications: Life Science
For research use only. Not intended for diagnostic or therapeutic use.