DATASHEET
Formulation
White Solid
Storage:
RT
Product Information:
Rho-associated kinase inhibitor (IC50 = 1.9 µM and 10.7 µM for Rho-associated kinase II and Rho-associated kinase respectively)1. Inhibits other kinases including cyclic nucleotide-dependent protein kinases.1 Reduces tryptamine-evoked vasopressor responses.2 attenuates bleomycin-induced pulmonary fibrosis in a mouse model.3 Clinically useful vasodilator.
Description:
CAS Number: 105628-07-7; Chemical Name: 1-(5-Isoquinolinesulfonyl)homopiperazine HCl; Molecular weight: 327.84; Formula: C14H17N3O2S · HCl; Solubility: DMSO (75 mg/ml) Water (100 mg/ml); Physical Properties: White solid; Purity: 98% by TLC, NMR (conforms)