bs-82415C

DATASHEET

Formulation White Solid

Storage: RT

Product Information:

Thalidomide analog which, like thalidomide,1 binds to cereblon which is the substrate recognition component of a cullin-dependent ubiquitin ligase and inhibits its autoubiquitination activity2. Induces degradation of T-cell repressors Ikaros (IKZF1) and Aiolos (IKZF3) leading to T cell activation2. Selective inhibition of IKZF1 and IKZF3 in multiple myeloma cells results in cell death3,4. Cell permeable. Caution: Teratogenic

Description:

CAS Number: 191732-72-6; Chemical Name: (R,S)-3-(4-Amino-1-oxo-3H-isoindol-2-yl)piperidine-2,6-dione; Molecular weight: 259.26; Formula: C13H13N3O3; Solubility: DMSO (30 mg/ml); Physical Properties: White solid; Purity: 98% by TLC, NMR (Conforms)

Size: 100mg, 500mg

Applications: Life Science(N/A)

For research use only. Not intended for diagnostic or therapeutic use.