bs-82422C [Life Science]
Sorafenib (base)
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Formulation Off-white solid

Storage: -20°C

Product Information:

Initially developed as a Raf kinase inhibitor, IC50 = 6 nM, but has been shown to inhibit many receptor tyrosine kinases including BRAF (IC50 = 22 nM); VEGFR-2 (IC50 = 90 nM); VEGFR-3 (IC50 = 20 nM); PDGFR-β (IC50 = 57 nM); Flt3 (IC50 = 58 nM); c-KIT (IC50 = 68 nM); FGFR-1 (IC50 = 580 nM)1. Paradoxically more potent in a cellular assay (IC50 = 20 nM) compared to an isolated enzyme assay (IC50 = 107 nM) for c-Fms2. Inhibits activation of MAPK pathway and ERK phosphorylation3. Induces caspase-independent apoptosis in melanoma cells4. Clinically useful anticancer agent.

Description:

CAS Number: 475207-59-1<br></br>Chemical Name: 4-(4-(3-(4-chloro-3-(trifluoromethyl)phenyl)ureido)phenoxy)-N-methylpicolinamide<br></br>Molecular weight: 464.83<br></br>Formula: C21H16ClF3N4O3<br></br>Solubility: DMSO (200 mg/ml) Ethanol (3 mg/ml)<br></br>Physical Properties: Off-white solid<br></br>Purity: 99% by TLC, NMR (Conforms)

Size: 10mg, 50mg

Applications: Life Science

For research use only. Not intended for diagnostic or therapeutic use.