bs-82427C
[Life Science]
Vismodegib
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support@biossusa.com
800.501.7654 [DOMESTIC]
+1.781.569.5821 [INTERNATIONAL]
support@biossusa.com
800.501.7654 [DOMESTIC]
+1.781.569.5821 [INTERNATIONAL]
DATASHEET
Formulation Off-white or beige solid
Storage: -20°C
Product Information:
A potent and selective Hedgehog (Hh) pathway signaling inhibitor antagonizing SMO with a Ki of 1.3 nM).1 Alters intracellular Ca2+ homeostasis and inhibits growth of cisplatin-resistant lung cancer cells.2 Inhibits two ABC transporters, ABCG2/BCRP and ABCB1/Pgp, IC50s=1.4 and 3.0 μM respectively.3 Clinically useful for the treatment of basal cell carcinoma.4 Inhibits proliferation and induces apoptosis in colon cancer cell lines.
Description:
CAS Number: 879085-55-9<br></br>Chemical Name: 2-Chloro-N-(4-chloro-3-(pyridine-2-yl)phenyl)-4-(methylsulfonyl)benzamide<br></br>Molecular weight: 421.30<br></br>Formula: C19H14Cl2N2O3S<br></br>Solubility: DMSO (200 mg/ml), Ethanol (10 mg/ml)<br></br>Physical Properties: Off-white or beige solid<br></br>Purity: 99% by TLC and HPLC NMR (Conforms)
Size: 5mg,25mg
Applications: Life Science()
For research use only. Not intended for diagnostic or therapeutic use.