bs-82428C [Life Science]
Vatalanib 2HCl
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Formulation White or off-white solid

Storage: -20°C

Product Information:

Potent, selective inhibitor of the VEGFR tyrosine kinases VEGFR-1 (Flt-1, IC50 = 77 nM) and VEGFR-2 (FLK-1/KDR, IC50 = 37 nM)1. Weaker inhibitor of other tyrosine kinases including PDGFR-β (IC50 = 580 nM), c-KIT (IC50 = 730 nM), FLT-4 (IC50 = 660 nM) and c-FMS (IC50 = 1.4 µM). Inactive against the EGFR, c-SRC, v-ABL, and protein kinase Cα (IC50 > 10 µM). Inhibits the growth of multiple myeloma cells in the bone marrow microenvironment2.

Description:

CAS Number: 212141-51-0<br></br>Chemical Name: N-(4-Chlorophenyl)-4-(4-pyridinylmethyl)-1-phthalazinamine dihydrochloride<br></br>Molecular weight: 419.73<br></br>Formula: C20H15ClN4 2HCl <br></br>Solubility: DMSO (20 mg/ml) Water (100 mg/ml)<br></br>Physical Properties: White or off-white solid<br></br>Purity: 98% by TLC, NMR (Conforms)

Size: 10mg, 50mg

Applications: Life Science

For research use only. Not intended for diagnostic or therapeutic use.