bs-82450C

DATASHEET

Formulation White Solid

Storage: -20°C

Product Information:

L-Cycloserine down-regulates sphingolipid biosynthesis via inhibition of serine palmitoyltransferase (3-ketodihydrosphingosine synthetase).1 The L isomer was shown to be 100-fold more potent than the D isomer at inhibition of the brain microsomal enzyme.1 It is a useful pharmacological agent for lowering sphingolipid levels in cells2 as well as in animal models3. Inhibition of de novo ceramide biosynthesis with L-cycloserine positively affected the senescent phenotype, restoring neuronal signaling and reducing mitochondrial dysfunction in a cortical neuronal model of senescence.4

Description:

CAS Number: 339-72-0; Chemical Name: (S)-4-Amino-3-isoxaolidinone; Molecular weight: 102.09; Formula: C3H6N2O2; Solubility: DMSO (20 mg/ml) with warming, Water (25 mg/ml); Physical Properties: White solid; Purity: 98% by TLC, NMR (Conforms)

Size: 100mg, 20mg

Applications: Life Science(N/A)

For research use only. Not intended for diagnostic or therapeutic use.