bs-82463C
[Life Science]
Pirfenidone
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support@biossusa.com
800.501.7654 [DOMESTIC]
+1.781.569.5821 [INTERNATIONAL]
DATASHEET
Formulation Off-white solid
Storage: RT
Product Information:
Antifibrotic agent. Prevents lung fibrosis in bleomycin-induced animal models.1 Down-regulates bleomycin-induced overexpression of lung procollagen I and III genes.2 Up-regulates RGS2 (Regulator of G-protein Signaling 2) which represents a new mechanism of pirfenidone action.3 Inhibits fibroblast proliferation.4 Suppresses TNFα production at the translational level.5 Scavenges hydroxyl radicals and inhibits lipid peroxidation in a dose-dependent manner.6 Recently approved therapeutic agent for idiopathic pulmonary fibrosis.7 Orally active.
Description:
CAS Number: 53179-13-8<br></br>Chemical Name: 5-Methyl-1-phenyl-2(1H)-pyridinone<br></br>Molecular weight: 185.23<br></br>Formula: C12H11NO<br></br>Solubility: DMSO (20 mg/ml)<br></br>Physical Properties: Off-white solid<br></br>Purity: 98% by TLC NMR (Conforms)
Size: 10mg, 50mg
Applications: Life Science
For research use only. Not intended for diagnostic or therapeutic use.