bs-82477C

DATASHEET

Formulation White solid

Storage: -20°C

Product Information:

Potent and selective prolyl-tRNA synthetase (PRS) inhibitor (Ki=18.3 nM) derived from febrifugine.1 Also attenuates TGF-β signaling, including reversibly reducing Smad3 protein levels and inhibiting fibroblast differentiation.2 Blocks fibrosis, angiogenesis, and tumor progression.2,3 Inhibition of PRS results in amino acid starvation which activates the integrated stress response (ISR) and mTOR signaling4 and thus preventing differentiation of TH17 cells, suppressing the autoimmune response5. Reduces TMPRSS2 protein levels via enhanced ubiquitination and proteasomal degradation, limiting SARS-CoV-2 cellular entry.6

Description:

CAS Number: 64924-67-0 Chemical Name: (2R,3S)-7-Bromo-6-chloro-3-[3-(3-hydroxy-2-piperidinyl)-2-oxopropyl]-4-3H-quinazolinone hydrobromide Molecular weight: 495.6 Formula: C16H17BrClN3O3 • HBr Solubility: DMSO (30 mg/ml) Physical Properties: White solid Purity: >98% by TLC NMR (Conforms)