bs-82478C

DATASHEET

Formulation Orange solid

Storage: -20°C

Product Information:

A naturally occurring quinone found in the bark of the Lapacho tree (Tabebuia avellanedae). A novel DNA topoisomerase I inhibitor which unlike camptothecin does not stabilize the cleavable complex indicating a novel mode of action.1 Induces apoptosis in a number of cancer cell lines.2 In cancer cells overexpressing NAD(P)H:quinone oxidoreductase, reduction of -lapachone leads to futile cycling between quinone and hydroquinone forms3 resulting in the production of reactive oxygen species4. Suppresses radiation-induced activation of NFB.5

Description:

CAS Number: 4707-32-8; Chemical Name: 3,4-dihydro-2,2-dimethyl-2H-naphtho[1,2-b]pyran-5,6-dione; Molecular weight: 242.27; Formula: C15H14O3; Solubility: DMSO (35 mg/ml) Ethanol (15 mg/ml; Physical Properties: Orange solid; Purity: 98% by TLC NMR (Conforms)

Size: 5mg, 25mg

Applications: Life Science(N/A)

For research use only. Not intended for diagnostic or therapeutic use.