bs-82506C [Life Science]
Rocaglamide
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Formulation White solid - presented as thin film on glass vial

Storage: -20°C

Product Information:

Rocaglamide is a potent inhibitor of NFkB in T-lymphocytes with almost complete inhibition at 200nM.1 It was able to completely inhibit IL-4 and IFN-γ production and suppress 60-85% of IL-2 and TNF-α production at 50nM in T-cells without inhibiting AP-1 and NF-kB (conversely, at concentrations <100nM, it was shown to increase NF-kB activity).2 Immunosuppression activity was due to inhibition of cytokine gene expression via blocking of NF-AT activity and is a different mechanism than suppression via Cyclosporine a and FK-506. Rocaglamide has anti-cancer properties via various pathways including ERK inhibition3, ATM/ATR-Chk1/Chk2 activation4, and p38 and JNK activation5.

Description:

CAS Number: 84573-16-0<br></br>Chemical Name: Natural product isolated from Phoma sp.<br></br>Molecular weight: 505.57<br></br>Formula: C29H31NO7<br></br>Solubility: DMSO Ethanol<br></br>Physical Properties: White solid - presented as thin film on glass vial<br></br>Purity: 97% by HPLC

Size: 2mg

Applications: Life Science

For research use only. Not intended for diagnostic or therapeutic use.