bs-82535C [Life Science]
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Formulation Colorless low melting point solid or viscous oil depending upon temperature

Storage: -20°C

Product Information:

PPARγ antagonist with μM affinity in 3T3-L1 and 3T3-F442A preadipocyte cells. Selective over PPARδ and PPARα. Antagonizes the ability of rosiglitazone to stimulate transcriptional activity of PPARγ and abolishes its anti-inflammatory effects in a mouse model1. Induces apoptosis via PPARγ-independent mechanisms2. Induces adipogenesis in human and mouse mesenchymal stromal stem cells and in mouse 3T3-L1 preadipocytes at low nM concentrations via a PPARγ independent mechanism3. Increases osteoblastogenesis and bone mass in a mouse model4. Active in vivo.

Description:

CAS Number: 1675-54-3; Chemical Name: 2,3-Bis[4-(2,3-epoxypropoxy)phenyl]propane; Molecular weight: 340.41; Formula: C21H24O4; Solubility: DMSO (30 mg/ml) Ethanol (15 mg/ml); Physical Properties: Colorless low melting point solid or viscous oil depending upon temperature; Purity: 95% by HPLC NMR (Conforms)

Size: 10mg, 50mg

Applications: Life Science(N/A)

For research use only. Not intended for diagnostic or therapeutic use.