bs-82621C
[Life Science]
PAC-1
www.biossusa.com
support@biossusa.com
800.501.7654 [DOMESTIC]
+1.781.569.5821 [INTERNATIONAL]
support@biossusa.com
800.501.7654 [DOMESTIC]
+1.781.569.5821 [INTERNATIONAL]
DATASHEET
Formulation Off-White solid
Storage: -20°C
Product Information:
PAC-1 is a procaspase-activating compound, directly activating procaspase-3, producing caspase-3, EC50=0.22 μM.1 It is less potent at activating procaspase-7, EC50=4.5 μM. It induces apoptosis in a variety of cancer cell lines. The mechanism of activation involves sequestering inhibitory zinc ions thus allowing procaspase-3 to autoactivate.2 Sensitizes cancer cells to various chemotherapeutic agents.3
Description:
CAS Number: 315183-21-2; Chemical Name: 4-(Phenylmethyl)-1-piperazineacetic acid [[2-hydroxy-3-(2-propenyl)phenyl]-methylene]hydrazide; Molecular weight: 392.49; Formula: C23H28N4O2; Solubility: DMSO (35 mg/ml) Ethanol (15 mg/ml); Physical Properties: Off-white solid; Purity: 98% by HPLC, NMR (Conforms)
Size: 5mg, 25mg
Applications: Life Science(N/A)
For research use only. Not intended for diagnostic or therapeutic use.