bs-82628C

DATASHEET

Formulation White Solid

Storage: -20°C

Product Information:

A potent and selective cell permeable calpain inhibitor. Inhibits oxidative damage-induced apoptosis in PC12 cells and capsaicin-induced apoptosis in dorsal root ganglion neurons.1 It penetrates the blood-brain barrier and inhibits brain cysteine protease activity after systemic administration, ameliorating brain damage in a gerbil model of global ischemia.2 Displays neuroprotective effects in neurotrama rodent models.3 Calpain I Ki = 8 nM; Cathepsin B Ki = 24 nM in isolated enzyme assays. IC50 = 0.3 µM in intact cell assay.4

Description:

CAS Number: 88191-84-8; Chemical Name: N-Benzyloxycarbonylvalylphenylalaninal; Molecular weight: 382.45; Formula: C22H26N2O4; Solubility: DMSO (75 mg/ml); Physical Properties: White solid; Purity: 98% by HPLC NMR (Conforms)

Size: 5mg, 25mg

Applications: Life Science(N/A)

For research use only. Not intended for diagnostic or therapeutic use.