bs-82700C [Life Science]
ABT-737
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Formulation Yellow solid

Storage: -20°C

Product Information:

Inhibitor of anti-apoptotic proteins from the Bcl family: Bcl-2, Bcl-X(L), and Bcl-w (Ki < 1 nM) that causes regression of solid tumors in mice.1 Senolytic agent which disrupts aberrant p21 expression, inducing apoptosis in senescent cells, and enhancing liver regeneration in mice.2,3 Acts synergistically to reduce cell viability when combined with CDK inhibitor purvalanol A in preclinical models of acute myeloid leukemia (AML).4

Description:

CAS Number: 852808-04-9<br></br>Chemical Name: 4-[4-[(4′-Chloro[1,1′-biphenyl]-2-yl)methyl]-1-piperazinyl]-N-[[4-[[(1R)-3-(dimethylamino)-1-[(phenylthio)methyl]propyl]amino]-3-nitrophenyl]sulfonyl]-benzamide<br></br>Molecular weight: 813.43<br></br>Formula: C42H45ClN6O5S2<br></br>Solubility: DMSO (5 mg/ml)<br></br>Physical Properties: Yellow solid<br></br>Purity: 98% by HPLC, NMR (Conforms)

Size: 5mg, 25mg

Applications: Life Science

For research use only. Not intended for diagnostic or therapeutic use.