bs-82749C [Life Science]
KY-226
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Formulation Off-white solid

Storage: -20°C

Product Information:

KY-226 (CAS 1621673-53-7) is a selective allosteric protein tyrosine phosphatase 1B (PTP1B) inhibitor (IC50 = 250 nM) with no activity at PPARγ.1 It significantly reduced plasma glucose, triglyceride, and A1c levels without weight gain in db/db mice.2 It has been suggested that KY-226’s anti-diabetic effects occur via enhancements in insulin signaling and anti-obesity effects via leptin signaling enhancements.2 KY-226 has also been shown to protect neurons from cerebral ischemia.3 This effect is mediated by restoration of tight junction proteins via activation of the Akt/FoxO1 pathway.4

Description:

CAS Number: 1621673-53-7<br></br>Chemical Name: 4-(Biphenyl-4-ylmethylsulfanylmethyl)-N-(hexane-1-sulfonyl)benzoylamide<br></br>Molecular weight: 481.67<br></br>Formula: C27H31NO3S2<br></br>Solubility: DMSO (>25 mg/mL)<br></br>Physical Properties: Off-white solid<br></br>Purity: >98% TLC

Size: 5mg, 25mg

Applications: Life Science

For research use only. Not intended for diagnostic or therapeutic use.