bs-82785C
[Life Science]
ML277
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support@biossusa.com
800.501.7654 [DOMESTIC]
+1.781.569.5821 [INTERNATIONAL]
DATASHEET
Formulation White Solid
Storage: -20°C
Product Information:
ML277 is a potent (EC50 = 260 nM) activator of Kv7.1 with selectivity against Kv7.2, Kv7.4, and Kv11.1 (hERG).1 ML277 enhances cardiac delayed rectifier K+ currents (IKs) in human iPSC-derived cardiomyocytes from normal and long QT-interval syndrome afflicted patients suggesting potential therapeutic use in long QT-interval syndrome.2,3 It displayed cardioprotective effects against ischemia in cellular and whole-heart models.4
Description:
CAS Number: 1401242-74-7; Chemical Name: (2R)-N-[4-(4-Methoxyphenyl)-2-thiazolyl]-1-[(4-methylphenyl)(sulfonyl]-2-piperidinecarboxamide; Molecular weight: 471.59; Formula: C23H25N3O4S2; Solubility: DMSO (20 mg/ml); Physical Properties: White solid; Purity: >98% by HPLC NMR (Conforms)
Size: 5mg, 25mg
Applications: Life Science(N/A)
For research use only. Not intended for diagnostic or therapeutic use.