bs-82803C

DATASHEET

Formulation Off-White solid

Storage: -20°C

Product Information:

LY2603618 is a potent (IC50 = 7nM) and selective (>1000x over Chk2) Checkpoint kinase 1 (Chk1) inhibitor.1 Chk1 is an important regulator of the DNA damage response – combination treatment of LY2603618 with other chemotherapeutic agents significantly increased tumor growth inhibition when compared to chemotherapeutic alone.2,3,4 LY2603618 caused a dramatic suppression of cell growth in MCF-7 and MDA-MB-231 human breast cancer cells via Chk1 inhibition induced upregulation of replication stress caused by oncogenes.5

Description:

CAS Number: 911222-45-2; Chemical Name: N-[5-bromo-4-methyl-2-[(2S)-2-morpholinylmethoxy]phenyl]-N'-(5-methyl-2-pyrazinyl)urea; Molecular weight: 436.30; Formula: C18H22BrN5O3; Solubility: DMSO (>10 mg/ml); Physical Properties: Off-white solid; Purity: 98% by HPLC, NMR (Conforms)

Size: 5mg, 25mg

Applications: Life Science(N/A)

For research use only. Not intended for diagnostic or therapeutic use.