bs-82818C
[Life Science]
PITSTOP2
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support@biossusa.com
800.501.7654 [DOMESTIC]
+1.781.569.5821 [INTERNATIONAL]
DATASHEET
Formulation Pink solid
Storage: -20°C
Product Information:
PITSTOP2 inhibits clathrin-mediated endocytosis via blockade of endocytic ligand association with the clathrin terminal domain leading to clathrin coat assembly inhibition.1 It was able to cause a collapse of the nucleocytoplasmic permeability barrier and a reduction of Importin-ß binding.2 PITSTOP2 reduced viability in HeLa cells by trapping dividing cells in metaphase through loss of mitotic spindle integrity.3
Description:
CAS Number: 1332879-52-3<br></br>Chemical Name: N-[(5Z)-5-[(4-Bromophenyl)methylidene]-4-oxo-1,3-thiazolidin-2-ylidene]naphthalene-1-sulfonamide<br></br>Molecular weight: 473.36<br></br>Formula: C20H13BrN2O3S2<br></br>Solubility: DMSO (>30 mg/ml)<br></br>Physical Properties: Pink solid<br></br>Purity: >98% by TLC NMR (Conforms)
Size: 5mg, 25mg
Applications: Life Science
For research use only. Not intended for diagnostic or therapeutic use.