bs-82822C
[Life Science]
Siramesine
www.biossusa.com
support@biossusa.com
800.501.7654 [DOMESTIC]
+1.781.569.5821 [INTERNATIONAL]
support@biossusa.com
800.501.7654 [DOMESTIC]
+1.781.569.5821 [INTERNATIONAL]
DATASHEET
Formulation White solid
Storage: -20°C
Product Information:
Siramesine (Lu 28-179) is a 2 selective agonist (IC50’s: 1 = 17nM, 2 = 0.2nM).1 It produced non-sedating potent and long-last anxiolytic effects in rodents.2 Siramesine induced caspase-independent programmed cell death in various cancer cell lines via increased levels of ROS and lysosomal leakage.3,4,5 Mitochondrial destabilization via loss of membrane potential and increased ROS has also been offered as a mechanism of action for the triggering of cell death by Siramesine.6
Description:
CAS Number: 147817-50-3<br></br>Chemical Name: 1’-[4-[1-(4-Fluorophenyl)indol-3-yl]butyl]spiro[1H-2-benzofuran-3,4’-piperidine; <br></br>Molecular weight: 454.59<br></br>Formula: C30H31FN2O<br></br>Solubility: DMSO (>25 mg/ml)<br></br>Physical Properties: White solid<br></br>Purity: 98% by HPLC NMR (Conforms)
Size: 5mg, 25mg
Applications: Life Science
For research use only. Not intended for diagnostic or therapeutic use.