bs-82853C

DATASHEET

Formulation White Solid

Storage: -20°C

Product Information:

Very potent (IC50 = 0.9 nM) inhibitor of vascular endothelial growth factor receptor 2 (VEGFR-2).1 It also inhibited PDGFRα (IC50 = 67 nM), c-Kit (IC50 = 40 nM), and FGFR2 (IC50 = 170 nM). Ki8751 completely suppressed HUVEC growth at 1 nM. Ki8751 completely inhibited tumor growth in LC-6 human tumor xenografts @ 5mg/kg. Ki8751 displayed anti-influenza A and B activity via disruption of virus entry in a PDGFRß/GM3-dependent manner.2

Description:

CAS Number: 228559-41-9; Chemical Name: N-(2,4-Difluorophenyl)-N’-[4-[(6,7-dimethoxy-4-quinolinyl)oxy]-2-fluorophenyl]urea; Molecular weight: 469.42; Formula: C24H18F3N3O4; Solubility: DMSO (15 mg/ml); Physical Properties: White solid; Purity: >98% by HPLC NMR (Conforms)

Size: 5mg, 25mg

Applications: Life Science(N/A)

For research use only. Not intended for diagnostic or therapeutic use.