bs-82859C

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Formulation Off-white/beige solid

Storage: -20°C

Product Information:

Inhibitor of the Heat Shock Transcription Factor 1 (HSF1) stress pathway (IC50 = 19 nM Inhibition HSF-1 mediated HSP72 induction, IC50 = 40 nM HSPA1A induction).1 It displayed efficacy in a human ovarian carcinoma xenograft mouse model (SK-OV 3 cells) and inhibited migration of WM266.4 melanoma cells @ 100 nM. CCT251236 showed high affinity for the protein pirin (Ki = 28 nM), but this target was not shown conclusively to be the cause of the anticancer activity. It also showed efficacy in vitro against primary patient-derived myeloma cells and H929 human myeloma xenograft models.2

Description:

CAS Number: 1693731-40-6 Chemical Name: N-[5-(2,3-Dihydro-1,4-benzodioxine-6-carbonylamino)-2-methylphenyl]-2-(2-pyrrolidin-1-ylethoxy)quinoline-6-carboxamide Molecular weight: 552.63 Formula: C32H32N4O5 Solubility: DMSO (5 mg/ml) Physical Properties: Off-white/beige solid Purity: 98% by HPLC NMR (Conforms)