bs-82868C

DATASHEET

Formulation Pale yellow solid

Storage: -20°C

Product Information:

SBI-553 is a potent, brain penetrant, and orally bioavailable allosteric modulator of neurotensin receptor 1 (NTSR1; EC50 = 340 nM)).1 It acts as a ß-Arrestin-biased agonist and selectively antagonizes G protein signaling conferring profound ß-Arrestin bias towards the endogenous ligand.2,3 SBI-553 displayed efficacy in mouse models of psychostimulant abuse without the characteristic undesirable side effects of unbiased NTSR1 agonism. This functionally selective modulation of NTSR1 may be a new therapeutic approach to treating psychostimulant abuse and other chemical and behavioral addictions.

Description:

CAS Number: 1849603-72-0; Chemical Name: 2-[[2-(1-Fluorocyclopropyl)-4-[4-(2-methoxyphenyl)piperidin-1-yl)quinazolin-6-yl]methylamino]ethanol; Molecular weight: 450.56; Formula: C26H31FN4O2; Solubility: DMSO (12 mg/ml); Physical Properties: Pale yellow solid; Purity: >98% by HPLC NMR (conforms)

Size: 5mg, 25mg

Applications: Life Science(N/A)

For research use only. Not intended for diagnostic or therapeutic use.