bs-82880C

DATASHEET

Formulation White Solid

Storage: -20°C

Product Information:

PF-06840003 (198474-05-4) is a potent (IC50 = 150 and 410 nM via two methods) and selective inhibitor of Indoleamine-2,3-dioxygenase (IDO1).1 In mice with syngeneic tumor grafts, it reduced intratumoral kynurenine levels by over 80%, inhibited tumor growth as monotherapy, and increased the efficacy of anti-PD-L1 therapy.2 PF-06840003 treatment combined with GM-CSF-secreting allogenic pancreatic tumor cell vaccine (GVAX) resulted in increased antitumor efficacy in a murine model of pancreatic ductal adenocarcinoma.3

Description:

CAS Number: 198474-05-4; Chemical Name: 3-(5-Fluoro-1H-indol-3-yl)pyrrolidine-2,5-dione; Molecular weight: 232.21; Formula: C12H9FN2O2; Solubility: DMSO (>25 mg/ml); Physical Properties: White solid; Purity: 98% by TLC NMR (Conforms)

Size: 10mg, 50mg

Applications: Life Science(N/A)

For research use only. Not intended for diagnostic or therapeutic use.