bs-82895C [Life Science]
HPI-1
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Formulation Yellow solid

Storage: -20°C

Product Information:

HPI-1 is a Hedgehog pathway inhibitor acting downstream of Smo and independently of PKA, PI3K and MAPK. It can suppress Hh pathway activation induced by loss of Su(fu) or Gli overexpression. Inhibits both endogenous and exogenous Gli1/Gli2 activity. IC50’s range from 0.2 to 6 µM for various cell-based assays.

Description:

CAS Number: 599150-20-6 (anhydrous)<br></br>Chemical Name: 2-Methoxyethyl 1,4,5,6,7,8-hexahydro-4-(3-hydroxyphenyl)-7-(2-methoxyphenyl)-2-methyl-5-oxo-3-quinolinecarboxylate<br></br>Molecular weight: 463.52 (anhydrous)<br></br>Formula: C27H29NO6·xH20<br></br>Solubility: DMSO (25 mg/ml) Ethanol (25 mg/ml)<br></br>Physical Properties: Yellow solid<br></br>Purity: >98% (TLC: 80% Ethyl acetate/hexanes; Rf = 0.37)

Size: 5mg, 25mg

Applications: Life Science

For research use only. Not intended for diagnostic or therapeutic use.