bs-82899C

DATASHEET

Formulation solid

Storage: -20°C

Product Information:

Tubastatin A is a potent and highly selective inhibitor of HDAC6 (IC50 = 15 nM, >1000-fold selectivity against other HDAC isoforms, approx. 60-fold versus HDAC8).1 It displayed anti-inflammatory and anti-rheumatic effects in Freund’s competitive adjuvant induced animal model of inflammation.2 Tubastatin A inhibited TNF-α (IC50 = 272 nM) and IL-6 (IC50 = 712 nM) in LPS stimulated human THP-1 macrophages.2 Tubastatin A has also been shown to have therapeutic potential for treatment of Alzheimers disease via altered amloid-β load and reduced tau hyperphosphorylation.3,4,5

Description:

CAS Number: 1310693-92-5; Chemical Name: N-Hydroxy-4-[(2-methyl-3,4-dihydro-1H-pyrido[4,3-b]indol-5-yl)methyl]benzamide hydrochloride; Molecular weight: 371.86; Formula: C20H22N3O2 · HCl; Solubility: DMSO or water; Physical Properties: solid; Purity: 99% by HPLC, NMR (Conforms)

Size: 5mg, 25mg

Applications: Life Science(N/A)

For research use only. Not intended for diagnostic or therapeutic use.