bs-82906C
[Life Science]
20(S)-Hydroxycholesterol
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support@biossusa.com
800.501.7654 [DOMESTIC]
+1.781.569.5821 [INTERNATIONAL]
DATASHEET
Formulation White Solid
Storage: -20°C
Product Information:
20-(S)-Hydroxycholesterol is an endogenous ligand for the LXR receptor.1 It has anti-adipogenic and pro-osteogenic effects in mesenchymal stem cells mediated via a non-LXR dependent pathway.2 The osteogenic effects of 20-(S)-hydroxycholesterol have been shown to be mediated by activation of hedgehog signaling and expression of genes associated with Notch signaling.3 Activation of Hedgehog is mediated via binding of 20(S)-hydroxycholesterol to Smoothened at a site distinct from the cyclopamine binding site.4,5
Description:
CAS Number: 516-72-3; Chemical Name: 5-Cholesten-3β, 20α-diol; Molecular weight: 402.66; Formula: C27H46O2; Solubility: DMSO or Ethanol; Physical Properties: White solid; Purity: 98% by TLC, NMR (Conforms)
Size: 5mg, 1mg
Applications: Life Science(N/A)
For research use only. Not intended for diagnostic or therapeutic use.