bs-82919C

DATASHEET

Formulation Pale yellow solid

Storage: -20°C

Product Information:

CB-839 is a potent (IC50 = 24 nM), selective and orally bioavailable inhibitor of glutaminase (KGA and GAC).1 CB-839 displayed an antiproliferative effect in the triple-negative breast cancer cell line, HCC-1806, but no activity in the estrogen receptor-positive cell line T47D. CB-839 was able to cause proliferation arrest and apoptosis in acute myeloid leukemia cells without causing cytotoxicity against normal human CD34(+) progenitors.2 Aspartate-glutamate carrier 1 (AGC1) inhibition can synergize with CB-839 to limit tumor growth.3

Description:

CAS Number: 1439399-58-2 Chemical Name: 2-(Pyridin-2-yl)-N-(5-(4-(6-(2-(3-(trifluoromethoxy)phenyl)acetamido)pyridazin-3-yl)butyl)-1,3,4-thiadiazol-2-yl)acetamide Molecular weight: 571.57 Formula: C26H24F3N7O3S Solubility: DMSO Physical Properties: Pale yellow solid Purity: >97% by HPLC: Agilent Poroshell 120 C18, 80/20 MeOH/water, 0.8 mL/min, 245 and 270 nm. NMR (Conforms)