DATASHEET
Formulation
White Solid
Storage:
-20°C
Product Information:
Potent (IC50 = 14 nM in vitro, 2.2 nM in human PC3 cells) and very selective (>100-fold over hABHD6, >200-fold over hPLA2G7) inhibitor of monoacylglycerol lipase (MAGL).1 Active in a rat formalin pain test at 3mg/kg. Orally bioavailable and CNS penetrant.
Description:
CAS Number: 1446817-84-0; Chemical Name: 1,1,1,3,3,3-Hexafluoropropan-2-yl-4-[[2-(pyrrolidin-1-yl)-4-(trifluoromethyl)phenyl]methyl]piperazine-1-carboxylate; Molecular weight: 507.4; Formula: C20H22F9N3O2; Solubility: DMSO (>25 mg/ml); Physical Properties: White solid; Purity: 98% by HPLC NMR (Conforms)