bs-82939C

DATASHEET

Formulation White Solid

Storage: -20°C

Product Information:

TH588 is a first-in-class nudix hydrolase family inhibitor.1 MTH1/NUDT1 is a family member that “sanitizes” oxidized deoxynucleotide triphosphates (dNTP) preventing their incorporation into DNA and thus avoiding DNA damage and cell death. TH588 inhibits MTH1/NUDT1 (IC50 = 5 nM) leading to cell death in several cancer cell lines while not affecting normal cells. Active in vitro and in vivo. Recent evidence has raised doubts about the cancer-killing ability of MTH1 inhibition.2,3

Description:

CAS Number: 1609960-31-7 (free base); Chemical Name: N4-Cyclopropyl-6-(2,3-dichlorophenyl)pyrimidine-2,4-diamine hydrochloride; Molecular weight: 331.63; Formula: C13H12Cl2N4·HCl; Solubility: DMSO (5 mg/ml); Physical Properties: White solid; Purity: 98% by TLC, NMR (Conforms)

Size: 5mg, 25mg

Applications: Life Science(N/A)

For research use only. Not intended for diagnostic or therapeutic use.