bs-82942C [Life Science]
Wnt-C59
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Formulation Tan Solid

Storage: -20°C

Product Information:

Wnt-C59 is a potent (IC50 = 74 pmol/L) inhibitor of Porcupine (PORCN), a Wnt-acyltransferase. Blockage of Wnt-acyltransferase prevents secretion of all Wnt isoforms. It was able to block progression of mammary tumors in MMTV-WNT1 transgenic mice.1 Wnt-C59 strongly inhibited the growth of intestinal neoplasia in RZ-mutant mice. Wnt-C59 was able to efficiently differentiate pluripotent stem cells into cortical neurons (CTIP2+/COUP-TF1). Wnt-C59 was also able to dramatically attenuate kidney fibrosis via inhibition of collagen mRNA expression and expression of inflammatory cytokines.

Description:

CAS Number: 1243243-89-1<br></br>Chemical Name: 4-(2-Methyl-4-pyridinyl)-N-[4-(3-pyridinyl)phenyl]benzeneacetamide<br></br>Molecular weight: 379.46<br></br>Formula: C25H21N3O<br></br>Solubility: DMSO (7 mg/ml) Ethanol (6 mg/ml).<br></br>Physical Properties: Tan Solid<br></br>Purity: >98% by HPLC NMR (Conforms)

Size: 25mg, 5mg

Applications: Life Science

For research use only. Not intended for diagnostic or therapeutic use.