bs-82966C

DATASHEET

Formulation beige solid

Storage: -20°C

Product Information:

Inhibitor of 4-Hydroxyphenylpyruvate dioxygenase (HPPD; IC50 = 40 nM1 and 173 nM2) and is in clinical use for the treatment of hereditary tyrosinemia type 13. CD13+ cancer stem cells (CSCs) are dependent on aerobic metabolism of tyrosine - Nitisinone inhibition of tyrosine metabolism results in lowered availability of acetyl-CoA and fumarate for use in the citric acid cycle causing these CSCs to enter cell cycle, decreasing self-renewal, and making them more susceptible to chemotherapy.4 Nitisinone is a potential treatment option for cancers that rely on tyrosine metabolism.

Description:

CAS Number: 104206-65-7; Chemical Name: 2-[2-Nitro-4-(trifluoromethyl)benzoyl]cyclohexane-1,3-dione; Molecular weight: 329.23; Formula: C14H10F3NO5; Solubility: DMSO (>10 mg/ml) Ethanol (10 mg/ml); Physical Properties: Beige solid; Purity: >98% by TLC (NMR Conforms)

Size: 50mg, 250mg

Applications: Life Science(N/A)

For research use only. Not intended for diagnostic or therapeutic use.