bs-82975C
[Life Science]
Lomitapide
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support@biossusa.com
800.501.7654 [DOMESTIC]
+1.781.569.5821 [INTERNATIONAL]
DATASHEET
Formulation White solid
Storage: -20°C
Product Information:
Lomitapide is a potent (IC50 = 8 nM) inhibitor of microsomal triglyceride transfer protein (MTP or MTTP) and is clinically useful in treating familial hypercholesterolemia.1,2 It has displayed anticancer activity acting through various pathways including autophagy-dependent cancer cell death via direct inhibition of the kinase activity of mTORC13, activation of AMPK/Beclin1-mediated autophagy4, Notch inhibition via targeting TACE and γ-secretase5, blocking ZDHHC5-dependent palmitoylation on SSTR56, PFKFB3 inhibition7, and PARP14/DRP1-mediated mitophagy8.
Description:
CAS Number: 182431-12-5<br></br>Chemical Name: N-(2,2,2-Trifluoroethyl)-9-[4-[4-[[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]piperidin-1-yl]butyl]fluorene-9-carboxamide<br></br>Molecular weight: 693.73<br></br>Formula: C39H37F6N3O2<br></br>Solubility: DMSO (50 mg/ml)<br></br>Physical Properties: White solid<br></br>Purity: >98% by HPLC NMR (Conforms)
Size: 25mg, 5mg
Applications: Life Science
For research use only. Not intended for diagnostic or therapeutic use.